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​Our lab focuses on lipids, with a particular interest in milk lipids. Milk has evolved over 200 million years to nourish mammalian offspring, making it an ideal system for studying lipids as both energy sources and bioactive molecules. Central to our research is the milk fat globule (MFG)—a unique lipid-protein structure that encapsulates milk lipids and plays a critical role in digestion, metabolism, immunity, and development.
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Since founding the lab in 2009, our mission has been to understand milk lipids at all levels: from their biosynthesis in the mammary gland to their health implications post-consumption. We approach this through three interconnected research themes:

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1. Mechanisms Regulating Milk Lipid Composition and Structure

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We study how metabolic status, diet, hormones, and environmental stress affect milk lipid synthesis and MFG size. Using in vivo, in vitro, and in situ models, we have shown how mitochondrial function and polar lipid composition influence lipid droplet formation. Our work has revealed dietary strategies—such as polyphenol supplementation—that support mitochondrial activity and modulate MFG traits, with implications for milk digestibility and health impact. These findings have also led to patent-pending applications, including hormone monitoring through milk.

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2. Understanding Dairy Fat Biosynthesis

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We investigate why ruminant milk has a uniquely diverse fatty acid profile. Using mammary epithelial cells and genetically modifiable yeast, we dissect the genetic and biochemical pathways that drive ruminant-specific milk fat synthesis. This knowledge can improve milk quality and inform bioengineering of milk fat alternatives.

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3. Health Implications of Native Milk Lipid Structures

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We explore how milk lipid structure influences growth, metabolism, immune function, and the microbiome. Our research spans from neonatal nutrition to elderly and medical dietary needs. We have shown that the structure of milk fat plays a critical role in its health effects and may help transition neonates from glucose- to fat-based metabolism.

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Translational Impact

Our lab has pioneered technologies to biomimic the structure and function of milk lipids. This includes co-founding two startups:

• A cultured milk platform that replicates MFG complexity.

• A microalgae-based platform to sustainably produce milk lipid alternatives at scale.

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Vision

Our long-term goal is to decode the biology of milk lipids to inform sustainable food production and improve global health. By bridging molecular insights with biotechnological innovation, we aim to develop next-generation, biomimetic food systems that address the nutritional needs of a changing world.

Keywords: 

Milk lipid globules; lipid macrostructure; triglyceride; polar lipids; membrane; diet; dairy.